University of Crete  |   X-ray Diffraction
 
DESCRIPTION

The 3D structure determination of proteins using X-ray Diffraction is one of the core services of our Infrastructure. Knowledge of the 3D structure of macromolecular targets of pharmaceutical and biotechnological interest and their complexes with small molecules or other proteins may reveal the structure-function relationships that dictate their mechanism of action. Proteins participate in a plethora of metabolic pathways and controlling their interactions with their counterparts or bioactive compounds may allow the development of therapeutic interventions with significant socioeconomic impact.

Potential users: Scientists working in academic/research organizations, health sciences, hospitals, industries (pharmaceutical, food, agricultural, biofuel, paper, chemical) and SMEs.

University of Crete
LOCATION:   Heraklion, Crete | http://en.uoc.gr/
RELEVANT STAFF:   Kathrin Kefala , Michael Kokkinidis
SERVICE DETAILS:  

Single crystal Xray diffractometer from Bruker is an X-ray generator which enables us to check crystals of various sizes and collect X-ray diffraction data from a single crystal sample. In addition to the single source configuration of the D8 QUEST, the larger enclosure of the D8 VENTURE hosts all the high intensity sources for working on even smaller, weakly diffracting crystals. The D8 VENTURE offers highest experimental flexibility, with excellent sample accessibility and visibility. It is engineered with high modularity from best-in-class components and is available in popular all-air-cooled configurations. The absolutely open design protects your investment with maximum flexibility for future extensions. It hosts the experimental setup in a more spacious enclosure that also provides room for rotating anode, revolutionary liquid metal X-ray source for structural biology, highest X-ray intensity in-house for even smaller and more challenging samples, self-regenerating target with Ga-radiation for lower background scattering and radiation damage, combination of two different wavelengths, fast and fully-automated wavelength switch.

RELEVANT EQUIPMENT:  
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D8 Quest by Bruker AXS
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DESCRIPTION:  

The D8 VENTURE hosts the experimental setup in a more spacious enclosure that also provides room for rotating anode, liquid metal jet and dual wavelengths solution. All systems feature the revolutionary PHOTON II CPAD detector.

The D8 VENTURE offers highest experimental flexibility, with excellent sample accessibility and visibility. It is engineered with high modularity from best-in-class components and is available in popular all-air-cooled configurations. The absolutely open design protects your investment with maximum flexibility for future extensions.


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