Functional characterization
| Scintillation Proximity radioligand binding Assay
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Analysis of protein-ligand interactions using His-tagged proteins captured on appropriate Scintillation Proximity Assay (SPA) scintillation beads in the presence of radiolabeled (tritiated) ligands, in conjunction with radioactivity measurements in a Tri-Carb Liquid Scintillation Counter.
Tri-Carb Liquid Scintillation Counter
Dr. Stathis Frillingos is Professor of Biological Chemistry at the University of Ioannina, Department of Medicine, and Director of the Interinstitutional Interdepartmental Programme of Postgraduate Studies in Molecular and Cellular Biology and Biotechnology at the University of Ioannina, Greece (http://msc-mcbb.ac.uoi.gr). His research team focuses on the analysis of structure-function-specificity and evolutionary relationships of membrane transporters, with current emphasis on Solute Carriers responsible for the transmembrane transport of nucleosides, nucleobases and their antimetabolite analogs. His research studies include the functional characterization of new nucleobase/nucleoside transporters from microorganisms and analysis of their binding-site interactions with inhibitors and antimetabolite compounds as potential antimicrobial drugs (http://www.frillingoslab.gr).
Tri-Carb Liquid Scintillation Counter